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KMID : 1161420230260060401
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Journal of Medicinal Food
2023 Volume.26 No. 6 p.401 ~ p.415
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Potential Mechanisms of Perillae folium Against COVID-19: A Network Pharmacology Approach
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XuHan Chen
Xu Xu
Jia Lv
Manaswita Tappata
LingLing Lyu
LiPing Liu
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Abstract
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In China, Perillae folium is widely used to treat colds, especially in the early stages of cold; the effect of taking P. folium is readily noticeable at that time. The active compounds and targets of P. folium were screened from Traditional Chinese Medicine Systems Pharmacology, Chinese Pharmacopoeia, and UniProt. Targets related to the initiation and progression of 2019 Coronavirus Disease (COVID-19) were retrieved from Online Mendelian Inheritance in Man and GeneCards. The potential therapeutic targets of P. folium on COVID-19 were the cross targets between them. Enrichment analysis of Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were conducted by using the Database for Annotation, Visualization and Integrated Discovery website. Molecular docking between key compounds and core targets was performed with AutoDock. The effects of P. folium extract and rosmarinic acid on inflammatory cytokines were tested by a cellular inflammatory model. The “Perillae folium-compound-target-COVID-19” network contained 11 kinds of compounds and 33 matching targets. There were 261 items in the GO functions (P?
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KEYWORD
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COVID-19, inflammatory factor, KEGG pathways, key compounds and targets, Perillae folium
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